Last updated: May 12, 2026
TL;DR / quick answer
Bryan Johnson's useful lesson is not "test everything." It is: test the right Blueprint biomarkers, repeat them, and act on trends.
Start with ApoB, Lp(a), HbA1c, fasting insulin/glucose, hs-CRP, full lipids, thyroid, sex hormones, liver and kidney function, vitamin D, B12/folate, ferritin, and homocysteine. Then pick the panel size that matches your budget and willingness to retest.
100+
current Blueprint biomarker framing
$365
official annual membership positioning
3-6 mo
realistic retest interval when optimizing
- Search intent: most readers want the Blueprint biomarkers list, Bryan Johnson's blood test results, current Blueprint blood test cost, his 0.48 aging-speed claim, and comparable bloodwork panels.
- Practical takeaway: compare panels by ApoB, Lp(a), insulin, HbA1c, hs-CRP, hormones, thyroid, liver/kidney, nutrients, ferritin, and homocysteine - not by inflated marker counts.
- Current product caveat: Blueprint's public offer now emphasizes a Biomarkers membership with 100+ biomarkers and 160+ yearly measurements; older reviews may still cite 108-marker or $375 Advanced Panel language.
- Where we can help: below are Blueprint-style blood panels we list by country, with more country-specific biomarker coverage planned.
Choose your testing path
Three useful versions of the Bryan Johnson blood test
Each tier groups the biomarkers worth measuring, the cadence, the cost, and panels we list that cover the scope. For markers Bryan has publicly reported, we show his actual value vs the longevity target and the population average.
Start with the markers that change decisions
Best if this is your first serious blood test or you want a simple annual baseline. These cover most of the decisions a longevity panel actually changes.
Cost range
$100-$250
Cadence
Every 6-12 months
Real options
Panels on Longevity.haus
Start here · 13 core markers
Get these even if you do nothing else.
- 01
ApoB
CardiovascularWhat: Counts every atherogenic (artery-clogging) lipoprotein particle in your blood — one ApoB per particle.
Why: The most decision-useful single number for heart-attack and stroke risk. Often diverges from LDL and changes treatment.[ref]
Bryan's context: Targets <80 mg/dL; reports values in the 60s mg/dL range.
- 02
HbA1c
MetabolicWhat: Percentage of haemoglobin coated with glucose — an integrated average of blood sugar over the past ~3 months.
Why: Catches pre-diabetes years before fasting glucose does. Cheap, stable, and meaningful for cardiovascular and dementia risk.[ref]
Bryan's reported result
Bryan 4.8% Target <5.0% Avg 5.4-5.7% - 03
Fasting glucose
MetabolicWhat: Blood sugar after an overnight fast — the snapshot complement to HbA1c.
Why: Interpreted together with HbA1c and fasting insulin, it separates "good glucose because of good insulin" from "good glucose because the pancreas is working overtime."[ref]
- 04
Fasting insulin
MetabolicWhat: How much insulin your pancreas releases at rest to keep blood sugar in range.
Why: The earliest-moving metabolic marker. Often rises years before HbA1c or glucose look abnormal.[ref]
- 05
hs-CRP
InflammationWhat: High-sensitivity marker of systemic inflammation made by the liver in response to immune signalling.
Why: Persistently elevated levels predict heart attack, stroke, and many age-related diseases — independent of cholesterol.[ref]
Bryan's reported result
Bryan Undetectable Target <0.5 mg/L Avg 1.0-3.0 mg/L - 06
Full lipid panel (LDL, HDL, triglycerides)
CardiovascularWhat: The classic cholesterol breakdown. LDL carries cholesterol into vessel walls; HDL clears it; triglycerides reflect dietary fat and metabolic strain.
Why: Baseline cardiovascular picture every clinician understands. Worth keeping even once you have ApoB — the ratios add context.[ref]
Bryan's reported result
LDL (calculated) Bryan 35 mg/dL Target <100 mg/dL Avg 100-130 mg/dLHDL Bryan 55 mg/dL Target >50 mg/dL Avg 40-50 mg/dLTriglycerides Bryan 42 mg/dL Target <100 mg/dL Avg 100-150 mg/dLTotal Cholesterol Bryan 101 mg/dL Target <200 mg/dL Avg 190-210 mg/dL - 07
TSH (thyroid stimulating hormone)
HormonesWhat: Signal the pituitary sends to push the thyroid gland — high TSH usually means an underactive thyroid is being pushed harder.
Why: Subclinical thyroid issues are common and can mimic fatigue, weight, lipid, and mood symptoms people misattribute to aging.[ref]
- 08
Liver function (ALT, AST, GGT)
Organ functionWhat: Enzymes that leak from liver cells under stress. GGT also tracks oxidative stress and alcohol load.
Why: Fatty liver is now common even in non-drinkers; abnormal enzymes are an early signal that diet and metabolic health are off.
Bryan's reported result
Bryan 7.5 U/L Target <25 U/L Avg 15-40 U/L - 09
Kidney function (creatinine, eGFR, cystatin C)
Organ functionWhat: Markers the kidneys clear from blood at predictable rates — eGFR translates them into a filtration percentage.
Why: Kidney decline is silent. Catching slow drift matters because many longevity supplements and drugs are renally cleared.
- 10
Vitamin D (25-OH)
NutritionalWhat: The storage form of vitamin D, made from sun exposure and dietary fat.
Why: Deficiency is very common, easy to fix, and tied to immune, bone, and mood outcomes.[ref]
Bryan's context: Targets 60–80 ng/mL.
- 11
Ferritin (+ iron studies)
NutritionalWhat: Storage protein for iron; together with transferrin saturation, it shows whether iron is too low or too high.
Why: Both extremes drive symptoms and risk. High ferritin is also an inflammation flag; low ferritin is a common fatigue cause.
- 12
B12 and folate
NutritionalWhat: Cofactors that the body needs to make red blood cells, DNA, and several neurotransmitters.
Why: Deficiency is common in vegans, the elderly, and people on metformin or acid-reducing drugs — and can cause irreversible nerve damage if missed.
- 13
Homocysteine
CardiovascularWhat: Intermediate amino acid in B-vitamin metabolism. Elevated levels indicate inefficient methylation.
Why: Independent risk factor for cardiovascular disease and cognitive decline; usually cheap to fix with B6/B12/folate.[ref]
Bryan's reported result
Bryan 5.1 umol/L Target <7 umol/L Avg 8-12 umol/L
Get the wider Blueprint-style longevity panel
Best if you are changing training, diet, sleep, medication, or supplements and want trend data. Add these when you are actively optimizing or have specific risk factors.
Cost range
$250-$600
Cadence
Every 3-6 months if optimizing
Real options
Panels on Longevity.haus
+ 18 more on top of Tier 1
Adds depth where Tier 1 is too coarse — fasting insulin, ApoB, thyroid panel, hormones, micronutrients.
- 01
Lp(a) (Lipoprotein little-a)
CardiovascularWhat: A genetically determined "sticky" cholesterol particle similar to LDL but more atherogenic.
Why: Set largely by genetics, so test once. If high, you need more aggressive ApoB control. Most people never check it.[ref]
- 02
Full thyroid (free T3, free T4, reverse T3, TPO antibodies)
HormonesWhat: The active and inactive thyroid hormones plus the antibodies that drive Hashimoto’s.
Why: TSH alone misses central hypothyroidism, T4-to-T3 conversion problems, and early autoimmune thyroid disease.
- 03
Sex hormones (testosterone total + free, SHBG, oestradiol)
HormonesWhat: The principal anabolic hormones plus the binding globulin that decides how much is bioavailable.
Why: Drives energy, recovery, mood, bone density, libido — and gradually drifts from the mid-30s onward in both sexes.[ref]
Bryan's reported result
Bryan 782 ng/dL Target 700-900 ng/dL Avg 300-500 ng/dL - 04
DHEA-S
HormonesWhat: The most abundant adrenal steroid — precursor to several sex hormones.
Why: Declines roughly linearly with age and is a useful marker of overall adrenal reserve.[ref]
- 05
Cortisol (morning + diurnal)
HormonesWhat: Primary stress hormone with a normal daily rhythm: high on waking, low at night.
Why: Flat or inverted curves correlate with poor sleep, blunted recovery, and metabolic dysfunction.
- 06
IGF-1
HormonesWhat: Growth-hormone-driven anabolic signal that mediates most of HGH’s downstream effects.
Why: Very high values associate with cancer risk; very low values with frailty. Important context for anyone considering growth-related interventions.
- 07
Uric acid
MetabolicWhat: End-product of purine metabolism, cleared by the kidneys.
Why: Linked to gout, hypertension, kidney stones, and metabolic syndrome — often elevated quietly long before symptoms.
- 08
Omega-3 index (EPA + DHA in red cells)
NutritionalWhat: Percentage of red-cell membrane fatty acids that are EPA + DHA.
Why: Strong predictor of cardiovascular and all-cause mortality; one of the few nutrition markers that responds clearly to a single change.
- 09
Magnesium (RBC)
NutritionalWhat: Intracellular magnesium status — far more accurate than the usual serum magnesium test.
Why: Magnesium drives 300+ enzymatic reactions; deficiency is common and easy to miss on standard panels.
- 10
Fibrinogen
CardiovascularWhat: Acute-phase clotting protein.
Why: Adds independent cardiovascular and stroke-risk information on top of hs-CRP.
- 11
Complete blood count (CBC) with differential
Organ functionWhat: Red cells, white cells, platelets and their sub-populations — neutrophils, lymphocytes, monocytes, eosinophils.
Why: A small change in the neutrophil-to-lymphocyte ratio is one of the cheapest aging signals known. Anaemia and platelet drift also show up here first.
- 12
Comprehensive metabolic panel (electrolytes, albumin, glucose)
Organ functionWhat: Sodium, potassium, chloride, bicarbonate, calcium, glucose, BUN, creatinine, albumin, total protein.
Why: Catches dehydration, electrolyte drift, low albumin (a robust predictor of mortality), and kidney/liver context that ALT alone misses.
- 13
Apolipoprotein A1 (ApoA1)
CardiovascularWhat: Main structural protein on HDL particles — counts the HDL particles themselves, not just the cholesterol they carry.
Why: ApoB:ApoA1 ratio is one of the strongest blood predictors of heart-attack risk in INTERHEART and other large cohorts.[ref]
- 14
PSA (prostate-specific antigen)
Organ functionWhat: Protein the prostate gland releases into blood; rises with prostate inflammation, BPH, or cancer.
Why: Standard screening tool for men over 45. Trend over years is more useful than any single value.
- 15
Prolactin
HormonesWhat: Pituitary hormone with roles in stress, reproduction, and dopamine signalling.
Why: Elevations can blunt testosterone in men and drive cycle issues in women — often missed without a full hormone panel.
- 16
RBC zinc, copper, selenium
NutritionalWhat: Intracellular levels of three trace minerals critical for immune function, thyroid conversion, and antioxidant defence.
Why: Serum values are noisy; red-cell levels reflect months of intake. Imbalances (high copper / low zinc) are surprisingly common.
- 17
Vitamin B6 (pyridoxal-5-phosphate)
NutritionalWhat: Active form of B6, a cofactor in homocysteine clearance and neurotransmitter synthesis.
Why: Both deficiency and over-supplementation cause symptoms — and high-dose B-complex users often run too high without realising.
- 18
GGT trend + ALT/AST ratio
Organ functionWhat: GGT tracks oxidative stress; AST/ALT ratio shifts in alcoholic vs non-alcoholic liver disease.
Why: Catches fatty liver progression earlier than ALT alone. Rising GGT in a non-drinker is a useful metabolic warning.
Use the big panel only when the extra data has a plan
Best with clinician oversight, complex risk profiles, or a full longevity program. Specialist work — only useful when the basics are stable.
Cost range
$600-$2,000+
Cadence
Quarterly only with clinician oversight
Real options
Panels on Longevity.haus
+ 18 more on top of Tiers 1 & 2
Specialist markers — epigenetic clocks, advanced lipoproteins, toxicology, organ-age. Mostly action-less without a plan.
- 01
Advanced lipid fractionation (NMR LipoProfile, LDL particle size)
CardiovascularWhat: Breaks LDL into particle counts and sizes (small dense LDL vs large buoyant LDL).
Why: Refines ApoB further when the standard panel and ApoB disagree, or to track response to therapy.
- 02
Continuous glucose monitor (CGM)
MetabolicWhat: Wearable that samples interstitial glucose every few minutes for 10–14 days.
Why: Reveals real-life post-meal spikes and variability — much richer than a single fasting reading.
- 03
Epigenetic age (DunedinPACE / GrimAge / PhenoAge)
Biological ageWhat: DNA-methylation patterns translated into a "biological age" or "pace of aging" score.
Why: Useful for tracking trend after a clear intervention period. Not a replacement for blood work and should not drive treatment alone.
Bryan's reported result
Bryan 0.48 Target <1.0 Avg 1.0 - 04
Heavy-metal panel (mercury, lead, arsenic, cadmium)
ToxicologyWhat: Whole-blood or urine measurement of common environmental toxic metals.
Why: Worth a single look in people with high fish intake, well water, occupational exposure, or unexplained neuro / cardiovascular symptoms.
- 05
Specialty inflammation / autoimmune panel (IL-6, ANA, ferritin trend)
InflammationWhat: A broader inflammation read than hs-CRP alone, including cytokines and autoimmunity screens.
Why: Reserve for unexplained elevated hs-CRP, suspected autoimmune disease, or complex risk profiles under clinician guidance.
- 06
Lp-PLA2 (lipoprotein-associated phospholipase A2)
CardiovascularWhat: Enzyme produced inside atherosclerotic plaques — circulates bound to LDL.
Why: Refines residual cardiovascular risk in people with normal LDL/ApoB but a strong family history of early heart disease.
- 07
Oxidised LDL (oxLDL)
CardiovascularWhat: LDL particles that have been chemically oxidised — the form that is taken up by macrophages in artery walls.
Why: Quantifies oxidative stress on the lipid system; mostly useful for tracking response to antioxidants or after weight loss.
- 08
PCSK9
CardiovascularWhat: Enzyme that regulates how many LDL receptors the liver keeps on its surface.
Why: Useful when considering or already on PCSK9-inhibitor therapy (Repatha, Praluent). Not actionable without that context.
- 09
High-sensitivity troponin T (hs-cTnT)
CardiovascularWhat: Cardiac muscle protein released in tiny amounts during silent heart-muscle stress.
Why: A "ticking-heart" signal: low-grade elevation predicts heart failure and CV death in apparently healthy adults.
- 10
NT-proBNP
CardiovascularWhat: Hormone released by the heart when ventricles stretch under volume or pressure load.
Why: Earliest blood signal of heart-failure risk; useful baseline in anyone over 50, in hypertensives, or with structural heart history.
- 11
GDF-15
Biological ageWhat: Stress cytokine released by mitochondrial dysfunction — rises steeply with age.
Why: One of the strongest single-protein predictors of all-cause mortality and frailty in research cohorts. Still mostly research-grade clinically.[ref]
- 12
Organ-age / proteomic clocks (SomaLogic, Nightingale)
Biological ageWhat: Plasma protein panels translated into per-organ biological age scores (heart, liver, brain, kidney, immune).
Why: Identifies which organ is aging fastest — useful for targeting interventions when generic epigenetic age is too coarse.
- 13
Telomere length (LTL)
Biological ageWhat: Average length of the protective caps on chromosomes in white blood cells.
Why: Mostly a research marker. Useful for long-term trend tracking; single readings have wide noise and limited actionability.
- 14
Bone turnover markers (CTX, P1NP, DEXA correlate)
Organ functionWhat: CTX measures bone breakdown; P1NP measures bone formation. Together they show whether bone is gaining or losing mass.
Why: Pairs with DEXA: blood markers move months before density changes are visible on scan. Critical if doing rapamycin or calorie restriction.
- 15
Galleri (multi-cancer early detection)
ToxicologyWhat: Liquid-biopsy test for circulating tumour DNA across 50+ cancer types.
Why: Adds an early-detection layer on top of imaging. Still relatively new — false positives exist and require imaging follow-up.
- 16
Microbiome stool analysis
Organ functionWhat: 16S or shotgun metagenomic sequencing of gut bacteria — species, diversity, functional pathways.
Why: Bryan reports tracking gut composition. Clinical actionability is limited beyond probiotic/fibre adjustments, but useful for trend.
- 17
PFAS / per-fluorinated compounds
ToxicologyWhat: Persistent industrial chemicals ("forever chemicals") that accumulate in blood from food packaging, non-stick cookware, water.
Why: Linked to thyroid, immune, and lipid effects. Worth a single screen — fixable through avoidance and (slowly) blood donation.
- 18
Organic acids / urinary metabolomics
NutritionalWhat: Urine panel of mitochondrial, neurotransmitter, and microbial metabolites.
Why: Functional-medicine staple. Useful for tracking down vague metabolic or fatigue patterns; results need a clinician to interpret.
Educational ranges only. Lab ranges vary by country, method, sex, age, pregnancy status, medication, and clinical context.
Tier 0 — skip these
Popular tests with weak clinical validity
Bryan-adjacent and longevity-marketing tests we don't recommend starting with. They are sold confidently but rarely change treatment. Each item links to a Tier 1–3 marker that actually answers the same question.
- 01
IgG food sensitivity panels
Skip / deprioritisePitch: Marketed as "find out which foods are inflaming you" — usually 100+ foods, ~$200–$500.
Why skip: IgG is a normal exposure antibody, not an allergy or intolerance marker. Major allergy bodies (AAAAI, EAACI, CSACI) explicitly recommend against using it for diagnosing food sensitivity.[ref]
Do this instead: If you suspect food triggers, run an elimination diet under a registered dietitian. For real allergy, IgE testing — not IgG.
- 02
Hair mineral analysis
Skip / deprioritisePitch: Sold as a non-invasive way to read your "mineral status" and heavy-metal load from a hair sample.
Why skip: Results are heavily confounded by shampoo, dye, sweat, and external contamination, and different labs return different results from the same sample. Not validated for systemic mineral status.
Do this instead: RBC zinc/copper/selenium and serum ferritin / iron studies (both in Tier 1–2 above) actually move treatment.
- 03
Stand-alone "telomere age" report
Skip / deprioritisePitch: One-off telomere length test priced as your "biological age."
Why skip: Single readings have wide noise, weak correlation with the rest of your bloods, and almost no clinician will change a plan based on one number. Only useful as a multi-year trend.
Do this instead: If you want a biological-age score, DunedinPACE / GrimAge / PhenoAge (Tier 3) are better validated. Or just retest your Tier 1 markers — they move with intervention.
- 04
Provoked / chelated heavy-metal urine challenge
Skip / deprioritisePitch: Take a chelating agent, then test urine — clinic interprets the spike as evidence of heavy-metal toxicity.
Why skip: The chelator artificially mobilises stored metals; reference ranges are for un-provoked urine, so any result will look elevated. This is what most "detox" programs are sold on.
Do this instead: Plain whole-blood or unprovoked urine mercury, lead, arsenic, cadmium (Tier 3). Run it once if you have real exposure risk.
- 05
NAD+ blood level
Skip / deprioritisePitch: Pitched alongside NMN / NR supplements as proof you need to "raise your NAD."
Why skip: Blood NAD+ does not reflect tissue NAD+ in a clinically actionable way, no validated reference range exists, and no clinical decision is reliably tied to the result.
Do this instead: If you want metabolic-aging signal, fasting insulin + HbA1c + ApoB do far more work. Save the spend.
- 06
"Adrenal fatigue" / saliva cortisol-only panel
Skip / deprioritisePitch: Four-point saliva cortisol marketed as proof of "adrenal exhaustion" causing your fatigue.
Why skip: "Adrenal fatigue" is not a recognised endocrine diagnosis. The saliva curve gives some circadian information but cannot diagnose adrenal insufficiency, which is a real clinical condition diagnosed with ACTH stimulation.
Do this instead: If genuinely fatigued: TSH + free T4, ferritin, B12, vitamin D, fasting glucose, and a sleep / depression review first (all Tier 1).
This is the editorial-judgement section. Reasonable clinicians can disagree on the edges. If your doctor recommends one of these in a specific clinical context, that overrides a generic skip-list.
Bryan's Other Tests: MRI, CT, DEXA & Ultrasound
Blood work covers most longevity decisions, but imaging catches things blood can't see — early tumours, coronary plaque, structural heart issues, body composition. Default to Thailand for the cheapest credible price; US/EU for convenience.
Full-body MRI
What it is: Whole-body scan that screens 13+ organs for tumours, cysts, aneurysms, fatty liver, and structural disease — no radiation.
Why it matters: Catches occult cancers and vascular problems before symptoms. Bryan does an annual Ezra-style full-body MRI.
Where to get it
Thailand (Bangkok, Phuket)
Bumrungrad, Samitivej, BNH from ~$700–$1,200 USD — same scanners, no radiology backlog.
Czechia (Prague)
Comprehensive scans from ~€500–€900 in private clinics.
United States
Ezra full-body MRI ~$1,950–$5,995; Prenuvo ~$2,500.
Coronary calcium (CT CAC)
What it is: Low-dose CT scan that scores calcified plaque in the coronary arteries — a direct picture of accumulated cardiovascular damage.
Why it matters: Single most useful imaging test for cardiovascular risk over age 40. A zero score is strongly reassuring; a high score reframes ApoB targets and treatment urgency.
Where to get it
Thailand
Around $80–$200 USD at major Bangkok hospitals — often bundled into executive checkups.
United Kingdom
Around £150–£300 at private imaging centres.
United States
Cash pay typically $100–$400 at hospital imaging centres.
Carotid intima-media thickness (carotid ultrasound)
What it is: Ultrasound measurement of the inner wall thickness of the carotid arteries.
Why it matters: Non-invasive proxy for early atherosclerosis. Adds vascular-age context alongside ApoB and CT CAC.
Where to get it
Thailand
Around $40–$120 USD at major Bangkok / Phuket hospitals.
Eastern Europe
Around €60–€150 at private cardiology clinics.
United States
Cash pay typically $150–$400.
DEXA scan
What it is: Dual-energy X-ray absorptiometry — measures bone density, fat mass, lean mass, and visceral fat.
Why it matters: Best single measure of body composition and bone health. Useful for tracking strength-training, fasting, and longevity interventions.
Where to get it
Thailand
Around $50–$150 USD at major hospitals.
United Kingdom
Around £80–£200 at private clinics.
United States
Cash pay typically $150–$300 (full body composition, not just bone).
Echocardiogram + cardiac ultrasound
What it is: Ultrasound view of heart structure and function — chamber sizes, valve motion, ejection fraction.
Why it matters: Catches structural heart disease, valve issues, and subtle cardiomyopathy that bloods and CAC can miss.
Where to get it
Thailand
Around $80–$200 USD at major Bangkok hospitals.
Mexico / Eastern Europe
Around $100–$250 USD at private cardiology clinics.
United States
Cash pay typically $300–$1,000.
Prices are indicative cash-pay figures from recent published rates; verify directly with the provider. Imaging quality is broadly equivalent at major hospitals in Thailand, Czechia, Mexico, and the US — what varies is wait time, language, and price.
Clinic comparison
Bryan-style blood panels in United States
Showing 4 curated panels available in or near United States, ranked by location fit and price.
Quest Diagnostics
Local🇺🇸 United States
Fitness Profile — Nutrition Test
OneDayTests
🇬🇧 United Kingdom
Ultimate Performance Blood Test
i-Screen
🇦🇺 Australia
Science Training Check
HealthScreen Australia
🇦🇺 Australia
The HealthScreen Exam
Location signal: US. VPNs and corporate networks can be wrong, so use the full blood-testing directory if this is not your country.
Same panel, cheaper country: the medical-tourism math
Every tier above is also a flight away from a private hospital that runs the same bloodwork at a fraction of US / UK cash-pay prices. Below is the like-for-like comparison per tier — same accredited labs, often inside 24 hours.
Essential 80/20 baseline
~13 high-signal markers — ApoB, HbA1c, fasting insulin/glucose, hs-CRP, full lipids, TSH, liver/kidney, vitamin D, B12/folate, ferritin, homocysteine.
Usually pays
United States / United Kingdom
$300–$500 in the US (Quest, Labcorp direct-to-consumer); £200–£350 in the UK at private clinics.
In medical-tourism markets
~60–75% less$60–$200 cash-pay
Bangkok · Prague · Mexico City
Bumrungrad / Samitivej (TH), Aeskulab (CZ), Hospital Angeles (MX) — same accredited labs, often results inside 24 h.
Blueprint-style comprehensive
+ Lp(a), full thyroid, sex hormones + SHBG, DHEA-S, cortisol, IGF-1, uric acid, omega-3 index, RBC magnesium, fibrinogen, ApoA1.
Usually pays
United States / United Kingdom
$500–$1,200 in the US (Function Health $499, Empirical Health $349–$599, comprehensive panels $700–$1,200); £400–£800 in the UK.
In medical-tourism markets
~55–65% less$200–$500 cash-pay
Bangkok · Prague · Singapore
Bangkok hospitals bundle these as "executive health panels"; Prague private labs price à la carte; Singapore is mid-priced but very fast.
Maximal / specialist
+ Advanced lipid fractionation, CGM, epigenetic clocks, hs-cTnT / NT-proBNP, GDF-15, organ-age proteomics, bone-turnover, Galleri-style, microbiome, PFAS / heavy metals.
Usually pays
United States / United Kingdom
$1,500–$4,000+ in the US once advanced lipids, epigenetic clocks ($249–$499 alone), and Galleri ($949 alone) are stacked.
In medical-tourism markets
~55–70% less$500–$1,800 cash-pay (excl. epigenetic kit shipped from US)
Bangkok · Prague · Budapest
Eastern Europe + Thailand both run comprehensive specialist panels at private hospitals. TruDiagnostic / Galleri ship from the US so the home-kit price is the same wherever you are.
Indicative ranges from clinic-listed cash-pay rates we have inventory for vs typical US / UK direct-to-consumer pricing (Quest, Labcorp, Function Health, Empirical Health, OneDayTests). Verify against the live panel listing before booking.
Compare live panels
See which clinic runs your tier at the best price
Filter by country, biomarker count and panel scope across every blood-testing provider we list.
Four rules that decide the panel for you
If you only buy one cardiovascular upgrade
Add ApoB and Lp(a). Standard LDL can miss particle burden and inherited risk.
If you care about metabolic health
Pair HbA1c with fasting insulin and fasting glucose. HbA1c alone can look fine while insulin is already high.
If you are comparing panels
Ignore the headline biomarker count until you confirm the specific markers. A 70-marker panel with ApoB, Lp(a), insulin, hs-CRP, hormones, thyroid, iron, and vitamins can beat a 100-marker panel padded with duplicate CBC/CMP line items.
If results come back abnormal
Use a clinician. This page is educational; changing medication, hormones, iron status, or aggressive supplementation based on one test is not a safe DIY workflow.
Blueprint Protocol Evolution: 2021 to 2026
The overlooked part of Bryan Johnson's protocol is that he stops things. Biomarkers are used as feedback, not just as content.
Launched Project Blueprint. Went public with $2M/year protocol. Built team of 30+ doctors.
Protocol refinement. Extensive supplement stack development. Continuous biomarker tracking.
Started/stopped HGH (side effects). First gene therapy (Follistatin). Young blood plasma from son (discontinued). Launched Rejuvenation Olympics. Dr. Oliver Zolman departure.
Stopped exogenous testosterone (achieved 782 ng/dL naturally). Blueprint consumer products launched. Total plasma exchange. Started HBOT protocol (Nov).
HBOT 60-session results: hs-CRP undetectable, 300% VEGF increase. Dropped Rapamycin after 5 years. "Best biomarkers ever" achieved.
Immortals Program launched ($1M/year, 3 slots). Reduced NMN to 6x/week. Added lithium + NDGA. Expanding Blueprint to comprehensive platform.
Biological Age Tests: Useful, But Not the Starting Point
Bryan Johnson's protocol popularized epigenetic clocks such as DunedinPACE, GrimAge, PhenoAge, Horvath, and organ-age models. These are interesting tracking tools, but they should not replace basic clinical blood work.
When it is worth adding
- You already track core blood markers.
- You can afford repeat testing, not a one-off novelty score.
- You understand that clocks can disagree with each other.
- You want trend data after a clear intervention period.
What not to do
- Do not buy an epigenetic test before ApoB, HbA1c, insulin, hs-CRP, thyroid, and nutrient markers.
- Do not change medication or hormones based on one age score.
- Do not compare one vendor's clock directly against another vendor's clock.
- Do not treat "younger" as proof that a specific supplement worked.
Criticisms and Limitations
- N=1 problem: Bryan's results are not a randomized trial and cannot prove which intervention caused which change.
- Confounding: diet, sleep, exercise, doctors, devices, medications, imaging, and budget all move together.
- Reference ranges: "optimal" is not the same as medically necessary, and aggressive targets can create risk.
- Product bias: Blueprint is now a consumer health company, so official product claims should be read as marketing plus data, not neutral clinical guidance.
- Replication risk: prescription drugs, hormones, iron manipulation, rapamycin-like interventions, and extreme supplementation require medical supervision.
Sources & References
Plain reading list. The numbered [ref] tags on biomarkers above link directly to specific peer-reviewed studies on PubMed; this is the higher-level material.
- Blueprint — Biomarkers (official). Bryan Johnson’s current consumer product framing: 100+ biomarkers, 160+ yearly measurements, two test rounds per year. https://blueprint.bryanjohnson.com/pages/biomarkers
- Blueprint — current public results. Bryan’s publicly shared result dashboard. Values change as he updates his protocol. https://protocol.bryanjohnson.com/Current-Results-Diet-Supplements
- NIH PubMed. Primary peer-reviewed evidence source for the biomarker citations [1]–[N] above. https://pubmed.ncbi.nlm.nih.gov
- ACC/AHA cardiovascular risk guidance. Reference framework for ApoB / Lp(a) / lipid targets used in clinician-led longevity practice. https://www.acc.org/Guidelines
- TruDiagnostic — DunedinPACE. Lab that runs the speed-of-aging epigenetic clock Bryan reports (0.48). https://www.trudiagnostic.com/
Frequently Asked Questions
What blood tests does Bryan Johnson get for longevity?
Bryan Johnson's Blueprint protocol emphasizes 100+ biomarker tracking across cardiovascular risk, metabolic health, inflammation, hormones, organ function, nutrients, and biological age. The practical starting point is not every exotic test: start with ApoB, Lp(a), HbA1c, fasting insulin/glucose, hs-CRP, full lipids, liver/kidney function, thyroid, sex hormones, vitamin D, B12/folate, ferritin, and homocysteine.
How often does Bryan Johnson get blood work done?
Bryan Johnson gets comprehensive blood panels every 3-6 months, epigenetic age testing twice per year, and a full-body Ezra MRI annually. He recommends consumers test every 6-12 months as a baseline, or every 3 months if actively optimizing their protocol.
How much does Bryan Johnson spend on blood testing?
Bryan Johnson's personal protocol has been reported at roughly $2 million per year, but that includes doctors, imaging, devices, supplements, and experimental interventions, not just blood work. Blueprint's current public Biomarkers membership is positioned around $365/year, billed annually, with two testing rounds per year and 100+ biomarkers. Comparable comprehensive panels from other providers usually cost about $190-$600 per test in the US/UK and can be cheaper in medical tourism markets.
What is Bryan Johnson's Blueprint protocol?
Blueprint is Bryan Johnson's comprehensive longevity protocol aimed at reversing biological aging. Started in 2021, it includes a strict 1,950-calorie vegan diet, exercise, sleep optimization, 100+ supplements, and extensive biomarker tracking. Johnson calls himself 'the most biologically measured person ever' with 33,537 biomarkers tracked. His speed of aging is 0.48, meaning he ages roughly half a year for every calendar year.
What is Bryan Johnson's biological age?
Bryan Johnson's speed of aging is 0.48 according to TruDiagnostic's DunedinPACE epigenetic clock, making him #1 out of 6,000+ participants in the Rejuvenation Olympics. At age 48, he ages 0.69 biological years per calendar year. His brain age is 42, and his VO2 max of 58.7 mL/(kg*min) places him in the top 1.5% of 18-year-olds.
Can I do Bryan Johnson's testing protocol on a budget?
Yes. Do not start by trying to copy every Blueprint measurement. A budget version should cover ApoB, Lp(a), HbA1c, fasting insulin and glucose, hs-CRP, a lipid panel, thyroid, sex hormones, liver and kidney function, vitamin D, B12/folate, ferritin, and homocysteine. Depending on country and lab access, that can be cheaper than a branded longevity membership while still covering the highest-signal decisions.
Where can I get Bryan Johnson style blood tests?
In the US, Blueprint, Function Health, Mito Health, Empirical Health, Quest, and Labcorp-style services cover many of the same categories. In the UK, providers such as OneDayTests and newer home/venous draw services cover many core markers. In Australia and Asia, comprehensive private panels can cover 50-100 biomarkers at lower prices. The key is not the brand name: verify ApoB, Lp(a), HbA1c, fasting insulin, hs-CRP, hormones, thyroid, liver/kidney function, vitamin D, B12/folate, ferritin, and homocysteine are included.
What biomarkers does Bryan Johnson track monthly?
Bryan Johnson discusses a high-signal core that includes HbA1c, hs-CRP, LDL, HDL, triglycerides, fasting glucose and insulin, testosterone or estradiol, DHEA-S, homocysteine, and vitamin D. For a modern Blueprint-style panel, add ApoB and Lp(a), because those are often more decision-useful for cardiovascular risk than standard cholesterol alone.
Is Bryan Johnson's longevity protocol worth it?
The full Blueprint protocol is not a normal consumer health plan; it includes doctors, imaging, devices, supplements, diet, training, and experimental decisions. The useful part for most readers is the measurement loop: get a baseline, change one or two things, retest, and use clinician-guided trends rather than guessing from symptoms or supplement marketing.
How do I start testing like Bryan Johnson?
Start with a baseline panel that includes cardiovascular, metabolic, inflammation, hormone, thyroid, liver, kidney, nutrient, and iron markers. Repeat in 3-6 months only if you are actively changing diet, medication, sleep, training, or supplements; otherwise annual or semiannual testing is more realistic. Add epigenetic age testing, MRI, CGM, or specialty tests only after the core blood markers are understood.
What advanced aging tests does Bryan Johnson use?
Bryan Johnson uses TruDiagnostic's TruAge COMPLETE for epigenetic age testing, measuring DunedinPACE, GrimAge, PhenoAge, Horvath's clock, and SYMPHONYAge (organ-system ages). He also tracks telomere length (increased 2.6% from 10.3 to 11.4 kb), telomerase activity (7.7%, adolescent level), and gets annual Ezra full-body MRI ($5,995) screening 13 organs for 500+ conditions.
What is Bryan Johnson's speed of aging?
Bryan Johnson's DunedinPACE speed of aging is 0.48, meaning he ages approximately half a year for every calendar year. This places him #1 out of 6,000+ participants in the Rejuvenation Olympics, which he founded in 2023. A score of 1.0 is average aging; below 0.5 is considered exceptional. He achieved a 14.71% improvement in his pace of aging.