PRP Facial (Platelet-Rich Plasma Rejuvenation)

PRP (platelet-rich plasma) facial rejuvenation using the patient's own concentrated growth factors to stimulate collagen production and skin renewal. Blood is drawn, centrifuged to concentrate the platelet fraction, and the resulting PRP is applied or injected into the skin. Treats fine lines, skin dullness, uneven tone, and early volume loss. Often combined with microneedling or fractional laser to enhance delivery. Results develop progressively over four to six weeks.

The PRP facial at Complexions Medical Spa Boston harnesses the regenerative capacity of the patient's own platelet-rich plasma to stimulate skin renewal through a natural, autologous growth factor delivery system. Platelet-rich plasma is prepared by drawing a small volume of the patient's venous blood — typically 10–30 mL — into tubes containing an anticoagulant, then centrifuging the sample using a calibrated protocol to separate the blood components by density. The centrifugation step concentrates the platelet fraction (which is normally present in whole blood at approximately 200,000 platelets per microliter) to a level approximately three to five times baseline, producing PRP with a platelet concentration of 600,000 to 1,000,000 per microliter. Activated platelets release their alpha-granule contents — a rich cocktail of growth factors including platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), insulin-like growth factor (IGF-1), and fibroblast growth factor (FGF). These growth factors act as signalling molecules that recruit fibroblasts, stimulate new collagen and elastin synthesis, promote angiogenesis (new capillary formation), and accelerate epidermal turnover. The PRP can be delivered to the skin by two methods at the practice. In combination with microneedling, the PRP is applied topically immediately after the microneedling session while the micro-channels are open, providing a transdermal delivery route past the stratum corneum barrier directly into the papillary dermis. As a standalone injectable facial, the PRP is injected intradermally or subdermally using a fine needle or cannula across the treatment area — similar to a mesotherapy technique — to deliver the growth factors at the precise anatomical depth where fibroblast stimulation is desired. The injectable approach is particularly suited to treating fine periorbital lines, the delicate under-eye area, neck rhytides, and diffuse skin quality improvement across the full face. Clinical results from PRP rejuvenation develop progressively over four to six weeks following each session as the stimulated collagen synthesis builds. A standard course of three sessions spaced four to six weeks apart is recommended for optimal outcomes, with maintenance sessions every six to twelve months thereafter to sustain the collagen-stimulating signal.