Microneedling with PRF & Boosters

Eternia MedSpa combines mechanical microneedling with Platelet-Rich Fibrin (PRF) derived from the patient's own blood to accelerate collagen production and skin renewal. Sessions start from $600, with a three-session course from $1,500. Optional boosters include exosomes, Salmon DNA/PDRN for under-eye and melasma concerns, and PDGF for deeper acne scarring.

Eternia MedSpa San Francisco offers advanced microneedling treatments that pair the mechanical collagen-induction effect of fine sterile needles with biological growth-factor boosters to deliver layered, customisable results. The baseline protocol combines standard microneedling with Platelet-Rich Fibrin (PRF) — a second-generation platelet concentrate prepared from the patient's own blood via centrifugation — which is rich in growth factors (PDGF, TGF-β, VEGF) and applied both topically and intradermally to stimulate fibroblast activity, collagen and elastin synthesis, and tissue vascularisation. Pricing starts at $600 per session, with a discounted three-session course from $1,500. A course of 3–4 sessions spaced 4–6 weeks apart is the standard recommendation for meaningful structural improvement. Initial glow and skin-tone improvements are visible within the first few days; textural changes in acne scars and pore size continue to develop over 3–6 months as new collagen matures and remodels. Eternia offers four booster tiers to target specific concerns. PRF (autologous platelet growth factors) is the standard included booster for general rejuvenation and suits most patients. PDGF concentrate provides an amplified mitogenic signal suited to deeper atrophic acne scars and photodamage. Exosomes are extracellular nanovesicles containing concentrated proteins and micro-RNA that drive marked improvements in skin glow, tone, and texture, representing the strongest available booster for overall skin quality enhancement. Salmon DNA/PDRN (Polydeoxyribonucleotide) provides a purine-rich substrate that promotes tissue repair and is particularly beneficial for crepey under-eye skin, melasma pigmentation, and rosacea-prone complexions. Clinical indications include atrophic acne scarring, surgical and trauma scars, enlarged pores, uneven texture, fine lines and periorbital wrinkles, photodamage and age spots, and loss of dermal firmness. Procedures are performed under topical anaesthetic; patients experience 1–2 days of redness comparable to mild sunburn before returning to normal activities.