i-Screen i-Screen

Intestinal Permeability (Leaky Gut) Check

Type

Blood Testing

Biomarkers

5

Duration

30 min

Results

3 days

Urine test to assess intestinal permeability.

Sexual health screening tests detect sexually transmitted infections (STIs) that often present with no symptoms at all. Many STIs — including chlamydia, gonorrhea, syphilis, HIV, and hepatitis B/C — can be carried asymptomatically for months or years while still being transmissible and causing internal damage. Blood-based STI panels typically screen for HIV (antibody/antigen), syphilis (RPR/VDRL), and hepatitis B and C. Urine or swab tests are usually needed for chlamydia and gonorrhea. Early detection is crucial because most STIs are curable with antibiotics when caught early, and even viral STIs like HIV can be managed effectively with modern antiretroviral therapy when detected promptly.

Key Details

Infections Screened
4–10 (varies by panel)
Fasting Required
No
Sample Type
Blood draw (urine for some infections)
Turnaround
1–5 business days
Confidential
Yes, results are private

Who Is This For?

Anyone who is sexually active and hasn't been tested recently. People starting a new relationship who want to know their status. Individuals who have had unprotected sex or multiple partners. Anyone experiencing symptoms like unusual discharge, sores, or painful urination. Routine screening as recommended by health guidelines (annually for sexually active adults).

What's Included

HIV 1/2 antibody/antigen (4th gen)
Syphilis (RPR/VDRL or specific antibody)
Hepatitis B surface antigen (HBsAg)
Hepatitis C antibody

Preparation Required

No fasting required. For the most accurate HIV results, test at least 2–4 weeks after potential exposure (window period varies by test type). Urine-based tests for chlamydia/gonorrhea require not urinating for at least 1 hour before sample collection.

Biomarkers Tested

5
Lactulose Recovery mg/dL

Lactulose is a 'large' molecule, and only small levels should be absorbed by the gut and excreted into the urine.

Mannitol Recovery mg/dL

Mannitol is a 'small' molecule which is readily absorbed by the gut and subsequently excreted into the urine.

Recovery Ratio Lactulose/Mannitol

Where 'leaky gut' is present, the large synthetic sugar molecules can penetrate the gut lining and are recovered in the urine, resulting in a high recovery ratio.

HIV (Current) reactive/non-reactive

Detects HIV-1 and HIV-2 antibodies and/or p24 antigen. Fourth-generation tests can detect infection as early as 2–4 weeks after exposure. Early detection enables treatment that can achieve viral suppression and prevent transmission.

Hepatitis C (anti-HCV) reactive/non-reactive

Detects antibodies to hepatitis C virus, indicating current or past infection. A positive result requires confirmatory RNA testing. Hepatitis C is now curable with direct-acting antiviral medications in most patients.

Frequently Asked Questions