Comprehensive Hormone Panel & Functional Hormone Evaluation

My Pure MD Houston runs a multi-layered hormone evaluation using saliva, urine, and blood testing to assess adrenal function (cortisol, DHEA, pregnenolone), estrogen metabolism pathways (2-OH, 4-OH, 16-OH estrogens and methylation markers), progesterone, testosterone, and thyroid hormones. The clinic prescribes bioidentical hormones including estradiol, progesterone, and testosterone in topical and oral forms. Conditions addressed include menopause, perimenopause, PCOS, infertility, and general hormonal imbalance. Results are interpreted by Dr. Kirmani and integrated into a personalised care plan.

Hormone evaluation at My Pure MD Houston goes well beyond a standard testosterone or estrogen blood draw. The clinic's functional medicine approach starts with understanding how hormones are produced, transported, converted, and cleared — mapping the entire hormonal ecosystem rather than treating a single out-of-range number. The adrenal axis is assessed via cortisol patterns across the day (diurnal rhythm matters, not just a snapshot), DHEA-S, and pregnenolone — the precursor steroid from which virtually all sex hormones and cortisol are synthesised. Low pregnenolone or disrupted cortisol rhythms explain fatigue, brain fog, and immune dysregulation that standard lab panels routinely miss. Estrogen metabolism testing distinguishes between the protective 2-hydroxyestrone pathway and the more reactive 4-hydroxyestrone and 16-hydroxyestrone pathways. Methylation markers (2-methoxyestrone, 4-methoxyestrone) indicate how efficiently the liver is detoxifying estrogen — relevant for both breast cancer risk assessment and symptom management in perimenopause and PCOS. This level of estrogen metabolite mapping is not typically available through conventional primary care or gynaecology. Thyroid evaluation covers TSH, free T3, free T4, and reverse T3 — capturing conversion efficiency and peripheral utilisation rather than relying on TSH alone. Blood sugar and insulin markers are included alongside the hormone panel because insulin resistance and cortisol dysregulation are tightly coupled to sex hormone imbalances, particularly in PCOS and metabolic syndrome. Once the lab picture is established, Dr. Kirmani prescribes bioidentical hormones — chemically identical to those the body produces — in topical cream, sublingual, or oral forms, calibrated to the patient's metabolism and symptom profile. Follow-up panels confirm that levels have reached the therapeutic range and that estrogen metabolism pathways are shifting in the right direction. Houston patients in Uptown, Galleria, River Oaks, Memorial, and the Energy Corridor can access the PNC Plaza clinic conveniently for both initial assessment and ongoing monitoring visits.